Biofunctionalized addressable polyelectrolyte based nanoparticles for the controlled release of drugs related to hard tissue regeneration ((06) M07)

• Subject Area: Preparatory and Physical Chemistry of Polymers ; Biomaterials
• Term: from 2010 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 107540325

In TP M7 the established drug delivery systems (DDS) are further improved in cooperation with M1, M2, M3, M4, M5, M9 concerning functionalization modalities of bone substituting materials (BSM) and in cooperation with B1, B5, B7, B13, B14 concerning novel biological tasks. In the chemical and analytical working package AP1 chemically reactive and thermoresponsive polymer units for switchable and multimodal drug release as well as biological ligands, antibodies and RNA for further specific interactions are integrated. In the biological working package AP2 the interaction of the BSM functionalized with optimized DDS with cell cultures and animal models is studied.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 79: Materials for Tissue Regeneration within Systemically Altered Bone
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Privatdozent Dr. Dietmar Appelhans; Privatdozent Dr. Martin Müller