Angiotensin II vermittelte Aktivierung des Rac Signalweges in glomerulären Podozyten

• Applicants: Professor Dr. Hermann Pavenstädt; Dr. Dirk Wolters
• Subject Area: Nephrology
• Term: from 2010 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 169965256

• Final Report Year: 2016

Final Report Abstract

In our funding period we have identified several new regulated proteins which are phosphorylated by Ang II in podocytes and confirmed the Ang II mediated phosphorylation of L-plastin, which may modulate the actin cytoskeleton of the podocyte. The network analysis achieves a deeper understanding of the partners involved in this complex Ang II induced phosphorylation scheme, which is relevant well beyond podocyte dysfunction.