Project Details
Projekt
The role of HCN channels in the septo-hippocampal circuit (B05)
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
from 2010 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580
The medial septum has an essential role for theta rhythm generation in the hippocampus and is critical for learning and memory. In this proposal we will address the question whether HCN channels in the medial septum are important for this rhythm. We will specifically knock out HCN2 in distinct subsets of medial septal neurons (global, GABAergic and glutamatergic) in the mouse. We will investigate how loss of HCN2 alters firing pattern in medial septal neurons in acute brain slices (aim #1) and in intact septo-hippocampal preparation (aim #2). In aim #3 we will characterize in vivo function of HCN2 using depth recording in anesthesized mice, EEG telemetry and behavioral experiments.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Heads
Professor Dr. Martin Biel, until 12/2013; Professor Dr. Christian Wahl-Schott
