In vivo functional analysis of dDRP

• Applicant: Professor Dr. Aurelio A. Teleman
• Subject Area: Developmental Biology
• Term: from 2010 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 167441013

• Final Report Year: 2013

Final Report Abstract

This research project was successful in that it went according to the plan set out in the grant proposal, and has generated interesting new biological insight into the regulation of cellular translation. We studied the in vivo function of the protein DRP. We found that DRP is required for efficient translation of a subset of mRNAs specifically when cells are actively proliferating. We discovered the cis-acting regulatory elements in this class of mRNAs which impart DRP-dependency. We show that impaired translation of these mRNAs leads to the impaired cell proliferation observed in DRP mutant animals.