Therapeutic impact of protease deficiency on breast cancer invasion and metastasis (B07)

To address whether the lysosomal proteases cathepsin B and D are essential for mammary cancer progression and tumor maintenance inducible Cre systems allowing for defined onsets of protease deficiencies in cancer or stromal cells will be employed. Interference of deficiencies with targeting PI3K/mTOR will be studied, since mTOR signaling is frequently dysregulated in breast cancer and the mTOR complex is associated with lysosomal membranes.

DFG Programme Collaborative Research Centres

Subproject of SFB 850:  Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis

Applicant Institution Albert-Ludwigs-Universität Freiburg

Project Heads Professor Dr. Christoph Peters; Professor Dr. Thomas Reinheckel