Role of JmjC domain-containing proteins in endothelial cell signaling and repair (B05)

• Subject Area: Cardiology, Angiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

The major aim of this project is to investigate the role of JmjC domain-containing proteins in endothelial cell function. JmjC domain-containing proteins play key roles as epigenetic regulators. Here, we will elucidate the mechanisms underlying the function of the two histone demethylases JMJD2B and JMJD3 in endothelial-mesenchymal transition and during adult neovascularization, respectively. Furthermore, we will establish a method to analyse the endothelial cell methylome with a subsequent functional analysis of interesting protein candidates.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Stefanie Dimmeler