Signalling pathways mediating endothelial flow sensing and inflammatory activation (A01)

• Subject Area: Pharmacology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

Endothelial responses to blood-borne mediators or mechanical stimuli are important determinants of vascular function. In the last funding period, we identified a signalling mechanism involving the cation channel Piezo1 and the Gq/G11-mediated signalling pathway, which plays an important role in endothelial sensing of laminar flow. The aim of the new funding period is to further analyse the composition of the upstream mechanism of endothelial flow sensing and the molecular mechanism of mechanotransduction linking initial mechanosensitive processes induced by laminar and disturbed flow with downstream effector functions in endothelial cells under normal and diseased conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Stefan Offermanns; Professorin Dr. Nina Wettschureck, until 12/2017