Protection against malaria can be achieved by experimental induction of liver-stage infection when the subsequent blood-stage is prevented by using attenuated sporozoites or by antimalarial treatment. The blood-stage is accompanied by induction of Tr1-like cells. These cells will be further characterized by “next-generation sequencing” and high-content flow cytometry. Different subsets of Tr1-like cells will be tested for their regulatory capacity especially wit regard to their capability to prevent liver-stage immunity.
DFG Programme
Collaborative Research Centres
