Immune-mediated liver inflammation occurs during viral and autoimmune liver disease and as a comorbidity of inflammatory bowel syndromes. Immune regulators such as IL-10 and Ceacam1 down-modulate inflammatory responses and affect the composition of the gut microbiota. Microbial metabolites, in turn, educate intestinal regulatory immune cells that are supposed to migrate into the liver. In our project, we will analyze how IL-10 and Ceacam1 affect immune regulation in immune-mediated liver damage via the gut-liver axis.
DFG Programme
Collaborative Research Centres
