Spinal cord regeneration: comparative analysis of miRNA-regulated pathways in salamander spinal cord regeneration versus mammalian CNS injury repair

• Applicant: Professorin Elly Margaret Tanaka, Ph.D., since 2/2012
• Subject Area: Developmental Biology
• Term: from 2009 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 157044246

• Final Report Year: 2017

Final Report Abstract

This work was one of the first studies to compare the microRNA transcriptional profile in the regenerative axolotl versus the non-regenerative rat after spinal cord injuries. It identified pathways that are differentially regulated in axolotl after spinal cord injury that promote a positive pro-generative circuitry to be activated and identified pathways that could be targeted in the non-regenerative rat to potentially promote better functional recovery after injury.

Publications

• Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: a cross-species comparison between salamander and rat. Dis Model Mech. 2014 Jun;7(6):601-11
  Diaz Quiroz JF, Tsai E, Coyle M, Sehm T, Echeverri K