Mechanismen der Evolution des Hepatitis C Virus - Bedeutung der Sequenzvariabilität für die antivirale Immunantwort (B01)

• Subject Area: Virology
• Term: from 2009 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 47100475

Analysis of Hepatitis C Virus (HCV) evolution can aid vaccine development by identification of regions under selection pressure by the immune system. In this project the influence of host genotypes on viral evolution will be analyzed for different genes that shape the immune response, and the impact of differential population allele frequencies in China versus Germany will be addressed. The earliest events of HCV transmission and evolution will be dissected by characterization of viral evolution during liver transplantation. Taken together, these studies will help to elucidate the determinants of HCV evolution and the impact of HCV sequence diversity on the immune Response.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 60: Mutual Interaction of Viruses with Cells of the Immune System: From Fundamental Research to Immunotherapy and Vaccination
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professor Dr. Daniel Hoffmann; Professor Dr. Jörg Timm, until 7/2014