Function and transcriptional regulation of a plant detoxification program

• Applicant: Professorin Dr. Christiane Gatz
• Subject Area: Plant Genetics and Genomics
• Term: from 2009 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 137317980

Plants are challenged by toxic chemicals that are either released by man, neighboring plants or pathogenic microbes. Moreover, endogenous reactive molecules accumulate under conditions of oxidative stress generated under adverse abiotic conditions or pathogen attack. Inactivation and elimination of harmful xenobiotic or endogenous substances is facilitated by an inducible set of detoxifying enzymes and transporters. Activation of at least part of this detoxification program can be triggered by xenobiotics like INA (2,6-dichloroisonicotinic acid), 2,4-D (2,4-dichlorophenoxyacetic acid) and TIBA (2,4,6-triiodobenzoic acid), as well as by high levels of salicylic acid. We have shown that the TGA family of bZIP transcription factors and the interacting GRAS protein SCL14 are important for this activation (Fode et al., 2008). We aim to obtain further insight into SCL14/TGA-dependent transcriptional control mechanisms in chemically stressed plants and to determine the importance of this pathway for the restriction of disease or stress symptoms.

• DFG Programme: Research Grants