Project Details
Projekt
Preclinical development and multimodal imaging of novel immunovirotherapeutics for cancer (C07)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
from 2009 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 68647618
Oncolytic viruses represent a novel class of cancer therapeutics, due to their intrinsic ability to selectively lyse infected tumor cells, while priming potent anti-tumor immune responses to provide lasting systemic immunity. We propose the combination of a novel pseudotyped vesicular stomatitis virus vector with adoptive T cell therapy as a powerful viro-immunotherapeutic strategy. We will employ multimodal and multiparametric imaging to noninvasively monitor the biodistribution and kinetics of the therapeutic agents, as well as to image specific biological changes to the local microenvironment in response to the therapy, in order to facilitate clinical translation and identify predictive biomarkers of response.
DFG Programme
Collaborative Research Centres
Applicant Institution
Technische Universität München (TUM)
Project Head
Privatdozentin Dr. Jennifer Altomonte
