Project Details
Projekt
Theranostic application of functionalized Hsp70-targeting nanoparticles for in vivo tumor imaging and drug delivery after radiotherapy (B04)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
from 2009 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 68647618
Hsp70 is frequently overexpressed in many different tumor types and presented on the plasma membrane (mHsp70) due to a tumor-specific lipid anchorage. Our fluorescently-labeled Hsp70-specific probes (antibody, Fab fragment, peptide) detect mHsp70 positive tumors and metastases in the sub-mm range in different mouse models. Due to a rapid endocytosis and retranslocation at 37°C, mHsp70 provides an ideal vehicle for a targeted drug delivery. Based on these findings, we will develop innovative Hsp70-functionalized nanoparticles with trimodal activities: improved tumor imaging/killing capacity after radiotherapy and stimulating of protective immunity.
DFG Programme
Collaborative Research Centres
Applicant Institution
Technische Universität München (TUM)
Project Head
Professorin Dr. Gabriele Multhoff
