A therapeutic approach to enhance innate defense mechanisms against toxins and venoms - mast cell proteases to the rescue

Applicant Professor Dr. Martin Metz

Subject Area Dermatology

Term from 2009 to 2015

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 125440970

Final Report Year 2019

Final Report Abstract

No abstract available

Mast cells orchestrate type 2 immunity to helminths through regulation of tissue derived cytokines. PNAS 2012;109:6644-9
M. R. Hepworth, E. Daniłowicz-Luebert, S. Rausch, M. Metz, C. Klotz, M. Maurer, S. Hartmann
(See online at https://doi.org/10.1073/pnas.1112268109)
A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity 2013;39:963-75
T. Marichal, P. Starkl, L.L. Reber, J. Kalesnikoff, H.C. Oettgen, M. Tsai, M. Metz, S.J. Galli
(See online at https://doi.org/10.1016/j.immuni.2013.10.005)
Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen Exposure. J Immunol, 2016;197:4240-4246
Gimenez-Rivera VA, Siebenhaar F, Zimmermann C, Siiskonen H, Metz M, Maurer M
(See online at https://doi.org/10.4049/jimmunol.1600236)
Human Mast Cell Tryptase Is a Potential Treatment for Snakebite Envenoming Across Multiple Snake Species. Front Immunol, 2018; 9:1532
Anderson E, Stavenhagen K, Kolarich D, Sommerhoff CP, Maurer M, Metz M
(See online at https://doi.org/10.3389/fimmu.2018.01532)