Influence of artificial and native extracellular matrices on adhesion and differentiation of mesenchymal stem cells and osteoblasts (B01)

• Subject Area: Orthopaedics, Traumatology, Reconstructive Surgery ; Cell Biology
• Term: from 2009 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 59307082

U. Hempel postulates that the pro-osteogenic effect of aECM/sGAG derivatives on MSC and osteoblasts is also due to changes in endogenous ECM (nECM). Therefore, sGAG-induced changes in the structure, composition and mechanics of the nECM as well as the phosphorylation status of ECM proteins will be characterized. On the other hand, intracellular interaction partners and signaling pathways of sGAG derivatives will be analyzed. Finally it will be studied whether aECM supports the osteogenic differentiation of hMSC from hair follicles and support hMSC from patients with impaired bone healing.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 67: Functional Biomaterials for Controlling Healing Processes in Bone und Skin - From Material Science to Clinical Application
• Applicant Institution: Universität Leipzig
• Project Head: Dr. Ute Hempel