Development and characterization of artificial extracellular matrices based on collagen and glycosaminoglycan derivatives (A03)

• Subject Area: Biomaterials ; Cell Biology
• Term: from 2009 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 59307082

The aim of V. Hintze is the characterization of aECM from fibrillar collagen and GAG derivatives as well as the analysis of the interaction of GAG with mediator proteins. In addition, further analyses are conducted on the regulatory function of GAG derivatives in the ECM remodeling by matrix metal proteinases. Ultimately, the transfer of these findings into the design of scaffolds is planned. The healing in soft and hard tissue can be specifically influenced by varying the stiffness and the incorporation of essential mediators into these scaffolds.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 67: Functional Biomaterials for Controlling Healing Processes in Bone und Skin - From Material Science to Clinical Application
• Applicant Institution: Universität Leipzig
• Project Heads: Privatdozentin Dr. Vera Hintze, since 7/2013; Professor Dr. Dieter Scharnweber, until 6/2017; Professor Dr.-Ing. Hartmut Worch, until 6/2013