The role of TRPC1 C4 C5 C6 and related proteins for Ca2+ signaling in mast cells

• Applicant: Professor Dr. Marc Freichel
• Subject Area: Dermatology
• Term: from 2009 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 124742924

• Final Report Year: 2019

Final Report Abstract

No abstract available

Publications

• TRPM4-mediated control of FcεRI-evoked Ca(2+) elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells. Sci Rep. 2016;6:32981
  Rixecker T, Mathar I, Medert R, Mannebach S, Pfeifer A, Lipp P, Tsvilovskyy V, Freichel M
  (See online at https://doi.org/10.1038/srep32981)
• Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis. Cell Calcium. 2018;71:24-33
  Tsvilovskyy V, Solís-López A, Schumacher D, Medert R, Roers A, Kriebs U, Freichel M
  (See online at https://doi.org/10.1016/j.ceca.2017.11.004)