Project Details
Projekt
Interference of the viral effector proteins pp71 and IE1 with ND10-mediated intrinsic immunity against human cytomegalovirus infections (B03)
Subject Area
Virology
Term
from 2009 to 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 52732026
We have demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB), is modified by viral effector proteins such as the pp71- or IE1-protein of human cytomegalovirus. This correlates with antagonization of a direct repressive function of PML-NB components that act as cellular restriction factors. Recent studies reveal an emerging role of PML-NBs as co-regulatory structures of further innate responses (e.g. IFN pathway). This proposal investigates how IE1 and pp71 are able to evade intrinsic and innate immune responses particularly governed by TRIM factors.
DFG Programme
Collaborative Research Centres
Applicant Institution
Friedrich-Alexander-Universität Erlangen-Nürnberg
Project Head
Professor Dr. Thomas Stamminger
