Structural biology of plant potyvirus and cytomegalovirus effector proteins
(A03)
Subject Area
Structural Biology
Term
from 2009 to 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 52732026
The structural determinants of plant potyvirus and metazoan cytomegalovirus (CMV) infection mechanisms will be characterized in A3. Higher oligomeric complexes formed by the CMV proteins IE1 and pUL50-pUL53 as well as plant potyvirus capsid proteins will be produced and crystallized. These crystallographic studies will be paralleled by fragment screening by X-ray crystallography efforts with available crystals of IE1 and pUL50-pUL53, crosslinking experiments and mutagenesis inquiries as well as in-depth studies by our collaborators from projects A2, A7, B3, C2 and C3.
DFG Programme
Collaborative Research Centres
