Project Details
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Analysis of the inflammatory bowel disease susceptome and resistome using a forward genetics approach

Subject Area Gastroenterology
Term from 2009 to 2011
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 112578275
 
Final Report Year 2011

Final Report Abstract

No abstract available

Publications

  • Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A, 2009 Mar 3;106(9):3300-5
    Brandl K., Rutschmann S., Li X., Du X., Xiao N., Schnabl B., Brenner D.A. and Beutler B.
  • NOD2 Regulates Dendritic Cell Function during Graft-versus-host Disease. Journal of Experimental Medicine, 2009; Sep 28;206(10):2101-10
    Penack O., Smith O.M., Cunningham-Bussel A., Liu X., Rao U., Yim N., Na I., Holland A.M., Ghosh A., Lu S.X., Jenq R.R., Liu C., Murphy G.F., Brandl K., van den Brink M.R.M.
  • The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. Journal of Immunology. 2009; Dec 15;183(12):7975-83
    Xiao N., Eidenschenk C., Krebs P., Brandl K., Blasius A.L., Xia Y., Khovananth K., Smart N.G., Beutler B.
  • MyD88-mediated signals in non-hematopoietic cells protect mice against DSS induced colitis by inducing specific EGFR ligands. Proc Natl Acad Sci U S A, 2010 Nov 16;107(46):19967-72
    Brandl K., Sun L., Neppl C., Siggs O.M., Le Gall S.M., Tomisato W., Li X., Du X., Maennel D.N., Blobel C.P., Beutler B.
 
 

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