Functions of the inflammatory response in tissue repair (B07)

• Subject Area: Dermatology ; Immunology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208

Repair of damaged tissue requires the coordinated action of inflammatory and tissue specific cells in time and space. We have shown that perturbation of these interactions leads to unsuccessful healing. Infiltrating cells of the monocyte-macrophage lineage sense a variety of environmental cues of injured tissue and integrate those into a repair response. We aim to understand the molecular and cellular networks in myeloid cells that coordinate their functional complexity during the sequential repair stages and how alterations in myeloid cell function contribute to pathological regenerative responses.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 829: Molecular Mechanisms Regulating Skin Homeostasis
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Sabine Eming