Based on the results of the previous funding period we now want to understand how membrane-associated MMP-14 contributes to the progression of epithelial and non-epithelial tumors of the skin, to vascular functionality and how it influences the response to therapy. We will also use the inducible endothelial cell and fibroblast-specific knockout mouse strains which we have generated to further analyse the influence of matrix alterations induced by MMP-14 ablation in tissue homeostasis and disease.
DFG Programme
Collaborative Research Centres
