Project Details
Projekt
Structure and function of microfibrillar and filamentous suprastructures in the dermis (B02)
Subject Area
Biochemistry
Term
from 2009 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208
Extracellular microfibrillar and filamentous suprastructures control tissue integrity and cell fate. We will study the physical and/or functional interaction between collagen VI and fibrillin microfibrils and the novel AMACO-containing suprastructure in the skin. We will investigate the organization of the AMACO-containing suprastructure, its cellular receptors and its integration into the Fraser complex. The in vivo functions of AMACO will be studied in a mouse model. Tumor samples in the CRC biobank will be screened for expression of the suprastructures to evaluate their potential as tumor markers.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität zu Köln
Project Heads
Professor Dr. Mats Paulsson; Professor Dr. Raimund Wagener
