Functional consequences of a redox regulated activation of calpain in diabetes (A16)

• Subject Area: Anatomy and Physiology ; Pharmacology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463

The project focuses on the calpain family of Ca2+-activated proteases and their endogenous inhibitor protein calpastatin (CAST) as well as on the role of the calpain/CAST proteins in processes usually attributed to redox signalling. Particular attention will be paid to regulation by microRNA and the consequences of calpain activation/inactivation on the mitochondrial proteome and function, including alterations in -ketoglutarate levels and the activity of members of the Jumonji C domain-containing histone lysine demethylase (Jmj-KDM) family.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 815: Redox-Regulation: Generating Systems and Functional Consequences
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Ingrid Fleming, Ph.D.