Mechanisms and consequences of a defect redox control of Kv4.3 channels in Morbus Parkinson (A13)

Subject Area Molecular Biology and Physiology of Neurons and Glial Cells
Anatomy and Physiology
Term from 2009 to 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463
 

Project Description

We aim to clarify the mechanisms that lead to an altered redox-state of Kv4.3 potassium channels and in turn to hyperactivity in dopamine substantia nigra (DA SN) neurons in a transgenic mutant alpha-synuclein mouse model of Parkinson disease (PD). By comparison with a CRISP/Cas-mediated redox-insensitive Kv4.3 mutant (C110), we aim to define the causal role of redox-mediated hyperactivity for selective neurodegeneration of DA SN neurons in PD.
DFG Programme Collaborative Research Centres
Subproject of SFB 815:  Redox-Regulation: Generating Systems and Functional Consequences
Applicant Institution Goethe-Universität Frankfurt am Main
Project Head Professor Dr. Jochen Roeper