Project Details

Professor Dr. Stephan A. Sieber

Address Technische Universität München (TUM)
Department Chemie
Lehrstuhl für Organische Chemie II
Lichtenbergstraße 4
85748 Garching

Projects

As Applicant
- Current projects
  - Deciphering the structure activity relationship, mode of action and uptake of isonitrile antibiotics in Gram-negative bacteria (Research Grants)
- Completed projects
  - A Proteomic Strategy for Inhibiting Cancer-Associated Enzymes (Emmy Noether International Fellowships)
  - Chemisch-proteomische Strategien zur Identifikation krankheitsassoziierter Enzyme in pathogenen Bakterien als neuartige Angriffsziele für Antibiotika (Independent Junior Research Groups)
  - A chemical proteomic strategy to identify novel drug targets in Plasmodium falciparum and corresponding lead compounds for the development of new antimalarials (Research Grants)
  - Protein targets of rugulactone and illudin S: An analysis of their function and mechanism of action (Research Grants)
  - Identification, validation and functional characterization of targets of myxobacterial compounds with potential for pharmacological cancer treatment (Research Units)
  - Identification of chemical compounds to inhibit the caseinolytic protease ClpXP complex and evaluate their biological activity (Research Grants)
  - Chemical-proteomic tools to monitor pyridoxal phosphorylation and its function as an enzyme cofactor in disease-related pathways (Research Grants)
  - Exploiting quorum sensing inhibition of the natural products fimbrolide and elegaphenone in gram-negative bacteria (Research Grants)
  - Chemical proteomic strategies for deciphering neocarzilin´s mode of action in cancer cells (Research Grants)
As Leader
- Completed projects
  - Hochauflösendes Ionenfallen Massenspektrometer mit HPLC (Major Research Instrumentation)
  - Hochauflösendes Ionenfallen Massenspektrometer (Major Research Instrumentation)
As Participating Researcher
- Completed projects
  - EXC 114: Munich Center for Integrated Protein Science (CIPSM) (Clusters of Excellence)
As Project Head
- Current projects
  - Functional characterization of carcinogenic and inflammatory secondary metabolites from the intestinal microbiota (Collaborative Research Centres)
- Completed projects
  - Reactivity and binding dynamic of small molecules in active centers (Collaborative Research Centres)
  - Small molecule induced conformational control of protein function and activity (Collaborative Research Centres)

Servicenavigation

Hauptnavigation

Professor Dr. Stephan A. Sieber

Additional Information

Servicenavigation

Hauptnavigation

Professor Dr. Stephan A. Sieber

Additional Information

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