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Professor Dr. Karl-Peter Hopfner

Address Ludwig-Maximilians-Universität München
Gene Center Munich
Feodor-Lynen-Straße 25
81377 München

Projects

As Applicant
- Current projects
  - Structural mechanism of sensing and processing of blocked DNA ends by the DNA double-strand break repair factor Mre11-Rad50 (Research Grants)
- Completed projects
  - Structural Biology of DNA damage sensors (Research Grants)
  - Structural and functional biology of the HP68 ABC ATPase (Research Grants)
  - Strukturelle Biochemie des Exosoms in der RNA Prozessierung (Research Grants)
  - Structural biology of vertebrate cGAS/Mab21 proteins and their ligand complexes (Research Grants)
  - The Evolution of T-cell Dysfunction in AML – Tailored Antibody-based Immunotherapy to Increase Response Rate and Overcome Innate and Adaptive Resistance (Research Grants)
As Leader
- Completed projects
  - Proteinkristallisationsanlage (Major Research Instrumentation)
  - Ultrahochauflösende LC-MS/MS Massenspektrometrieeinheit (Major Research Instrumentation)
As Spokesperson
- Completed projects
  - GRK 1721: Integrated Analysis of Macromolecular Complexes and Hybrid Methods in Genome Biology (Research Training Groups)
As Participating Researcher
- Completed projects
  - GRK 1202: Oligonucleotides in Cell Biology and Therapy (Research Training Groups)
  - GSC 1006: Graduate School of Quantitative Biosciences Munich (QBM) (Graduate Schools)
  - EXC 114: Munich Center for Integrated Protein Science (CIPSM) (Clusters of Excellence)
As Project Head
- Current projects
  - Mechanisms of Regulation and Information Processing by the INO80 Remodeler (Collaborative Research Centres)
  - Structural mechanism of MRN-ATM in DNA double-strand break signalling and processing (Collaborative Research Centres)
  - Structural mechanisms of self-nucleic acid sensing by cGAS (CRC/Transregios)
- Completed projects
  - Structural mechanism of the activation of RIG-I by viral RNA (Collaborative Research Centres)
  - Functional architecture of the INO80 chromatin-remodelling complex in DNA repair (CRC/Transregios)
  - Repair and Signaling of DNA Double-Strand Breaks in Normal and Malignant Hematopoiesis (Collaborative Research Centres)
  - Structural mechanism of the Swi2/Snf2 ATPases in genome expression and maintenance (Collaborative Research Centres)
  - Identifying and targeting escape mechanisms in AML using multispecific antibody derivatives (Collaborative Research Centres)
  - Structural Mechanisms of MALT1 Signaling in T-Cell Differentiation and Activation (Collaborative Research Centres)
  - Radioimmunotherapy of pancreatic cancer: combining biologically augmented radiotherapy with multi-functional release of immune checkpoints (Collaborative Research Centres)

As Prizewinner
- Gottfried Wilhelm Leibniz-Programm 2017

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