Professor Dr. Wolfgang Linke

Address Universitätsklinikum Münster
Institut für Physiologie II
Robert-Koch-Straße 27b
48149 Münster

Projects

As Applicant
- Current projects
  - In vivo titin cleavage by AAV9-mediated gene transfer in a genetic mouse model to determine the link between titin-based mechanical function and cardiac performance (Research Grants)
- Completed projects
  - Molekulare Mechanismen der Elastizität des quergestreiften Muskels: Analyse der Dehnbarkeit von Titin in isolierten Myofibrillen (Research Grants)
  - Funktionelle Charakterisierung des Sarkomer-Zytoskeletts in quergestreiften Muskeln (Heisenberg Fellowships)
  - Probing an active role of titin in modulating actin-myosin interactions (Research Grants)
  - Lastabhängige Veränderung der Expression und mechanischen Funktion von Titin und Titin-Liganden im Herzmuskel (Clinical Research Units)
  - Investigation of a reciprocal feedback between the transport and the cellular mechanostat functions of the nuclear envelope (Research Grants)
As Project Head
- Completed projects
  - Dynamic regulation of the sarcomeric cytoskeleton in muscle (Collaborative Research Centres)
  - Translational and posttranslational control of truncated titin proteins in cardiomyocytes from dilated cardiomyopathy patients (Collaborative Research Centres)
As Cooperation Partner
- Completed projects
  - Impact of elevated pre- and afterload on production of reactive oxygen species in cardiac myocytes (Research Grants)
As Co-Investigator
- Current projects
  - Renewal Proposal (HE 8530/3): Uncovering the molecular and structural role of titin and MyBP-C to skeletal and cardiac muscle performance. (Research Grants)