Professor Dr. Friedrich Koch-Nolte

Address Universitätsklinikum Hamburg-Eppendorf
Zentrum für Diagnostik
Institut für Immunologie
Martinistraße 52
20251 Hamburg

Projects

As Applicant
- Current projects
  - Engineering the avidity of nanobody-based bispecific diabodies and heavy chain antibodies to specifically target myeloma cells that co-express two membrane proteins (Research Grants)
  - ImmunoStroke: From Immune Cells to Stroke Recovery The role of gasdermin D in ischemic stroke (Research Units)
- Completed projects
  - Molekulare Klonierung und Charakterisierung humaner und muriner mono ADP-Ribosyltransferasen (Cholera- und Diphtherietoxinhomologe) (Research Grants)
  - Einsatz neuer Immunisierungsstrategien zur Produktion von Kameliden Schwereketten-Antikörpern als Enzyminhibitoren (Research Grants)
  - Molecular and functional analyses of CD25 as a target for ADP-ribosylation on CD4+/CD25+ regulatory T cells (Research Grants)
  - Production of camelid heavy-chain antibodies as specific enzyme inhibitors using new immunization strategies (Research Grants)
  - Molekulare Mechanismen der NAD-induzierten T-Zell Apoptose und der funktionellen Regulation vom Membranproteinen durch ADP-Ribosylierung (Research Grants)
  - Molecular mechanisms and functional consequences of P2X7 purinoceptor activation (Research Grants)
  - Molecular mechanisms and function of P2X7 ion channel gating on T cells (Research Grants)
  - Evaluation of P2X7 as a therapeutic target in autoimmune encephalomyelitis and in tumor immunity (Research Grants)
As Project Head
- Current projects
  - Purinergic receptors in adipose tissue inflammation and adaptive thermogenesis (Collaborative Research Centres)
  - Antibodies and nanobodies for adenine nucleotide research (Collaborative Research Centres)
  - Modulating immunity and inflammation via adenine nucleotides (Collaborative Research Centres)
- Completed projects
  - Bedeutung von Mono-ADP-Ribosyltransferasen für die Signalübermittlung im Immunsystem und die Pathogenese von Autoimmunerkrankungen (Collaborative Research Centres)
  - Molecular mechanisms and functional consequences of ADAM protease activation induced by extracellular NAD or ATP (Collaborative Research Centres)