Professor Dr. Axel Brakhage

Address Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V.
Hans-Knöll-Institut (HKI)
Abteilung Molekulare und Angewandte Mikrobiologie
Adolf-Reichwein-Straße 23
07745 Jena

Projects

As Applicant
- Completed projects
  - Melaninbiosynthesegene als Virulenzdeterminanten und cAMP-abhängige Signaltransduktion in dem opportunistisch human-pathogenen Pilz ASPERGILLUS FUMIGATUS (Research Grants)
  - Molekulare Regulation der Penicillinbiosynthese in Aspergillus nidulans: Transkriptionsfaktoren, Transkriptionskomplexe und deren Kommunikation (Research Grants)
  - Evolution und Funktion von cis-/trans-Elementen pilzlicher Sekundärmetabolismusgene am Beispiel der Penicillinbiosynthese in Aspergillus nidulans (Priority Programmes)
  - Identification of virulence determinants of the human-pathogenic fungus Aspergillus fumigatus by proteome analysis (Priority Programmes)
  - Holistic approach to genomics of human-pathogenic fungi: Data warehouse for integration of data on transcriptome, proteome and metabolome of Candida albicans and Aspergillus fumigatus (Priority Programmes)
  - Koordination des Schwerpunktprogrammes "Kolonisation und Infektion durch humanpathogene Pilze" (Priority Programmes)
  - Redox regulation, development and hyphal growth in Aspergillus nidulans (Research Units)
  - Novel molecular mechanisms of iron sensing and homeostasis in filamentous fungi (Research Grants)
  - Antimicrobial Effect of Nano-Rough Titanium Surfaces: Reduction of Microbial Adhesion and Mechanisms of Reduction (Research Grants)
  - AfuInf - Proteome and polysaccharidome of Aspergillus fumigatus at early stage of infection (Research Grants)
As Spokesperson
- Current projects
  - TRR 124: Pathogenic Fungi and their Human Host: Networks of Interaction - FungiNet (CRC/Transregios)
  - EXC 2051: Balance of the Microverse (Clusters of Excellence (ExStra))
- Completed projects
  - SPP 1160: Colonisation and Infection by Human-pathogenic Fungi (Priority Programmes)
  - GSC 214: Jena School for Microbial Communication (JSMC) (Graduate Schools)
As Participating Researcher
- Completed projects
  - GRK 745: Mucosal Host-Pathogen Interactions (Research Training Groups)
As Project Head
- Current projects
  - Cross-talk of Aspergillus fumigatus with neutrophilic granulocytes (CRC/Transregios)
  - Surface proteins of Lichtheimia corymbifera as virulence determinants (CRC/Transregios)
  - Central Tasks of the Collaborative Research Centre (CRC/Transregios)
  - Bacteria-triggered Activation of Fungal Silent Gene Clusters and Impact of Produced Compounds on Microorganisms (Collaborative Research Centres)
  - Macromolecular prodrug nanoparticles for antimicrobial therapy (Collaborative Research Centres)
- Completed projects
  - Molekulare Regulation der Penicillinbiosynthese in Aspergillus nidulans (Collaborative Research Centres)
  - Molekulare Mechanismen der Protektion und deren Regulation des lungen-pathogenen Pilzes Aspergillus fumigatus gegen Immuneffektorzellen (Collaborative Research Centres)