Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum
Klinik für Pädiatrie mit SP Onkologie und Hämatologie
Address
Augustenburger Platz 1
13353 Berlin
Deutschland
GERiT
This institution in GERiT
13353 Berlin
Projects
Clinical Research Units
Current projects
KFO 5023: BECAUSE-Y Berlin Center for Diagnosing, Understanding and Treating Antibody(Y)-mediated Neurological Diseases
(Spokesperson
Endres, Matthias
)
Preclinical development of antibody-specific novel immunotherapies
(Applicants
Künkele-Langer, Annette
;
Meisel, Andreas
;
Reincke, Momsen
)
Completed projects
Koordination der Klinischen Forschungsgruppe 109
(Applicant
Bornfeld, Norbert
)
Untersuchung der Rolle amplifizierter Gene auf Chromosom 6p für Pathogenese und Progression des Retinoblastoms
(Applicant
Grasemann, Corinna
)
Untersuchung der Rolle von Neurotrophinen und ihrer Rezeptoren für das biologische Verhalten von Retinoblastomzellen
(Applicant
Eggert, Angelika
)
Research Fellowships
Completed projects
Deciphering the mechanisms of intestinal stem cell elimination by allogeneic T cells in order to develop novel GVHD treatment approaches
(Applicant
Arnhold, Viktor
)
Deciphering the role of circular RNAs in the pathogenesis and therapy resistance of ALK-positive anaplastic large-cell lymphoma
(Applicant
Fuchs, Steffen
)
T cell therapy with L1-CAM-targeting chimeric antigen receptors (CAR) as immune therapy for neuroblastoma patients after haploidentical stem cell transplantation.
(Applicant
Künkele-Langer, Annette
)
The role of stromal cells (especially cancer-associated fibroblasts) in tumor development and metastasis.
(Applicant
Shalapour, Shabnam
)
Translation of the c-myc and n-myc Proto-Oncogenes by internal ribosomal entry sites (IRES)
(Applicant
Hundsdörfer, Patrick
)
Emmy Noether Independent Junior Research Groups
Completed projects
Recombinase-induced genomic structural variants in neuroblastoma (RecoN)
(Applicant
Henssen, Anton
)
Research Grants
Completed projects
Der Einfluß des humanen Zytomegalievirus (HCMV) auf zentrale Kontrollmechanismen des Zellzyklus und der zellulären DNA-Replikation
(Applicant
Wiebusch, Lüder
)
Funktionelle Charakterisierung der Proteine STEAP1 und LIPI zur Entwicklung Tumor-spezifischer Marker und selektiver Biotherapeutika für Ewing Tumore
(Applicant
Grünewald, Ph.D., Thomas
)
Induktion einer T-Zellantwort gegen das Colon-Karzinom assoziierte EpCam-Antigen: Grundlagen für eine therapeutische Vakzinierung
(Applicant
Pezzutto, Antonio
)
Kontrolle der lytischen HCMV-Infektion durch Cyclin A2-abhängige Phosphorylierung
(Applicant
Wiebusch, Lüder
)
The hidden bioactive molecules: miRNAs loaded in extracellular vesicles might act as bioactive constituents in European mistletoe
(Applicant
Xie, Ph.D., Wenyan
)
Research Units
Current projects
FOR 5628: Multiscale magnetic resonance elastography in cancer: The mechanical niche of tumor formation and metastatic spread – towards an improved diagnosis of cancer through mechanical imaging
(Spokesperson
Sack, Ingolf
)
Neuroblastoma as pediatric tumor model: in vivo mechanical niches in zebrafish and patients
(Applicants
Eggert, Angelika
;
Heeren-Hagemann, Anja
)
CRC/Transregios
Current projects
Engineering CAR-T cells against neuroblastoma with synthetic notch receptors to increase tumor-specificity and endogenous immune activation
(Project Head
Künkele-Langer, Annette
)
Collaborative Research Centres
Current projects
Central coordination of CRC1588
(Project Head
Eggert, Angelika
)
Deciphering the principles of neuroblastoma metastasis to the bone marrow by integrated single-cell and spatial multi-omics
(Project Heads
Eggert, Angelika
;
Haas, Simon
)
Engineering CAR T cells to better find and eradicate neuroblastoma
(Project Heads
Höpken, Uta Elisabeth
;
Künkele-Langer, Annette
)
Extrachromosomal DNA (ecDNA) evolution and re-integration as a driver of progression and metastasis
(Project Heads
Henssen, Anton
;
Schwarz, Roland
)
Molecular technology infrastructure and support
(Project Heads
Altmüller, Janine
;
Lodrini, Marco
;
Ralser, Markus
)
Neuroblastoma cell states and their link to the microenvironment, disease progression and therapy response
(Project Heads
Henssen, Anton
;
Junker, Jan Philipp
)
Plasma proteome and metabolome signatures to better understand, monitor and predict neuroblastoma evolution
(Project Heads
Deubzer, Ph.D., Hedwig E.
;
Ralser, Markus
)
Preventing neuroblastoma relapses by molecular characterization and targeted elimination of minimal residual disease cells
(Project Heads
Künkele-Langer, Annette
;
Versteeg, Rogier
)
SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
(Spokesperson
Eggert, Angelika
)
Spatial organization and function of RNA in primary neuroblastomas and their TME
(Project Heads
Eggert, Angelika
;
Rajewsky, Nikolaus
)
Support with preclinical animal models
(Project Heads
Dörr, Jan
;
Heeren-Hagemann, Anja
;
Schulte, Johannes Hubertus
)
Targeting MYCN-dependent resolution of transcription-replication conflicts
(Project Heads
Büchel, Gabriele
;
Henssen, Anton
)
Targeting MYCN multiprotein complexes in neuroblastoma with miniproteins
(Project Heads
Dörr, Jan
;
Wanker, Erich E.
)
The Neuroblastoma Evolution integrated research training group
(Project Heads
Blüthgen, Nils
;
Künkele-Langer, Annette
)
The post-translationally modified neuroblastoma proteome as a source for druggable vulnerabilities
(Project Heads
Dörr, Jan
;
Mertins, Philipp
)
The role of neuroblastoma-secreted exosomes in pre-metastatic niche formation
(Project Heads
Deubzer, Ph.D., Hedwig E.
;
Gerhardt, Holger
)
Completed projects
Development of tailored protocols for tolerance induction by immunoablation and hematopoietic stem cell transplantation in autoimmune diseases
(Project Heads
Alexander, Tobias
;
Arnold, Renate
;
Hiepe, Falk
)
Research Training Groups
Current projects
GRK 2424: Computational Methods for Oncology: Towards Personalized Therapies in Cancer
(Spokesperson
Blüthgen, Nils
)
NFDI technical and methodological consortia
Current projects
National Research Data Infrastructure for Immunology
(Spokesperson
Busse, Christian
)
