Paul-Ehrlich-Institut
Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel
Abteilung Medizinische Biotechnologie
Address
Paul-Ehrlich-Straße 51-59
63225 Langen
Deutschland
GERiT
This institution in GERiT
63225 Langen
Projects
Research Grants
Current projects
Identifying and overcoming CAR T cell barriers in the colorectal carcinoma microenvironment
(Applicants
Buchholz, Christian
;
Farin, Henner
)
Targeted Genomic Integration by Engineered Transposon and CRISPR/Cas9 Components
(Applicants
Ivics, Zoltan
;
Mussolino, Claudio
)
Completed projects
Entwicklung von rekombinanten Maus-Adenovirus-Vektoren
(Applicant
Wildner, Oliver
)
Entwicklung von tumorgerichteten replikations-kompetenten adenoviralen Vektoren zur Behandlung von hepatischen Kolonkarzinom-Metastasen
(Applicant
Wildner, Oliver
)
Functional characterization of the Harbi1 and Naif1 transposon-derived genes in vertebrates
(Applicant
Ivics, Zoltan
)
Generation of a Fanconi anemia models in the pig by advanced genome engineering
(Applicants
Ivics, Zoltan
;
Kues, Wilfried A.
)
Genetically capsid-modified adenovirus vectors as nanoparticle vaccines
(Applicant
Dittmer, Ulf
)
Modelling cerebellar pathology of Ataxia-Telangiectasia: Assessing ATM-deficient mice versus human iPS cells
(Applicants
Auburger, Georg
;
Ivics, Zoltan
)
Molecular evolution of retroviral envelope proteins guided by particle incorporation and membran fusion
(Applicant
Buchholz, Christian
)
Pathogenitätsrelevante Genregionen der Immundefizienzviren
(Applicant
Cichutek, Klaus
)
Preclinical Gene Therapy of Fanconi Anemia with Transposon-Based Approaches
(Applicant
Ivics, Zoltan
)
Roles of DNA repair pathways in Sleeping Beauty transposition in vertebrate cells
(Applicant
Ivics, Zoltan
)
Specific elimination of tumor stem cells using oncolytic viruses
(Applicant
Buchholz, Christian
)
Stable transfection in Schistosoma mansoni using transposons
(Applicant
Lucius, Richard
)
The Activator (Ac) element from maize: transposition mechanism and regulation and advancement as a mutagenesis tool
(Applicant
Kunze, Reinhard
)
Therapeutic gene delivery with Sleeping Beauty transposon vectors: Assessment of preclinical efficacy and safety in a mouse model of Gaucher disease
(Applicants
Ivics, Zoltan
;
Ohm, Thomas Georg
)
Priority Programmes
Completed projects
Assessing and improving the safety profile of Sleeping Beauty transposon-mediated gene transfer in human cells
(Applicant
Ivics, Zoltan
)
Cell entry targeted gene transfer into quiescent cells of the hematopietic system by surface engineered lentiviral vectors
(Applicant
Buchholz, Christian
)
Cell-type specific optogenetic manipulation for characterizing the role of inhibitory interneurons in motor cortex of non-transgenic animals
(Applicants
Buchholz, Christian
;
Diester, Ilka
;
Fries, Pascal
;
Khodosevich, Konstantin
;
Monyer, Hannah
)
Ein lentiviraler Vektor für die Transduktion von G0-arretierten Zellen. Analyse genetischer Determinanten
(Applicant
Cichutek, Klaus
)
Research Training Groups
Completed projects
GRK 1045: Modulation of Host Cell Functions to Treat Viral and Bacterial Infections
(Spokesperson
Dittmer, Ulf
)
GRK 1172: Research, Development and Safety of Biologicals
(Spokesperson
Pfeilschifter, Josef M.
)
