Max-Planck-Institut für Herz- und Lungenforschung
Abteilung für Entwicklung und Umbau des Herzens
Address
Ludwigstraße 43
61231 Bad Nauheim
Deutschland
GERiT
This institution in GERiT
61231 Bad Nauheim
Projects
Priority Programmes
Completed projects
Control of muscle precursor cell migration by inductive and cell autonomous signals
(Applicant
Braun, Thomas
)
Molecular mechanisms of lineage decisions mediated by Notch signalling in adult and embryonic hematopoietic development
(Applicant
Just, Ursula
)
Selection and manipulation of mesenchymal stem cells for the generation of myoblasts and cardiomyocytes
(Applicant
Braun, Thomas
)
Research Grants
Current projects
The role of osteoclasts and blood vessels as mediators downstream of beta-catenin in the differentiation of osteoblasts derived from two origins – chondrocytes and perichondrium
(Applicant
Hartmann, Christine
)
Completed projects
Die Satellitenzellen des Skelettmuskels: Kontrolle von Proliferation, Zellzyklusaustritt und Differenzierung während der Gewebsregeneration
(Applicant
Braun, Thomas
)
Dissection of signaling networks regulating stem cell maintenance and asymmetric cell division in developing and adult lung epithelia
(Applicant
Braun, Thomas
)
Entwicklung eines neuen adenoviralen Vektorsystems zur Herzmuskel-spezifischen Angiogenese bei ischämischer Kardiomyopathie
(Applicant
Zimmermann, René
)
Funktionelle Analyse der Rolle neuronaler bHLH Proteine bei der Bildung und Differenzierung neuronaler Zellen
(Applicant
Braun, Thomas
)
Funktion und Regulation der Nkx5-1 und Nkx5-2 Gene in der Innenohr- und neuronalen Entwicklung
(Applicant
Bober, Eva
)
Kontrolle von Differenzierungs- und Regenerationsvorgängen im geschädigten und alternden Herzmuskel
(Applicant
Braun, Thomas
)
Physiologische Bedeutung von Natrium-Bicarbonat-Cotransportern
(Applicant
Böttger, Thomas
)
Untersuchung des regulatorischen Effektes von BMP-10 auf Proliferations- und Apoptosevorgänge im adulten und alternden Mausherzen
(Applicant
Braun, Thomas
)
Collaborative Research Centres
Current projects
Control of innate immune cell trafficking and clearance by REG proteins in the diseased heart
(Project Heads
Braun, Thomas
;
Pöling, Jochen
)
Control of pulmonary vessels and the right heart by histone modifications and metabolism in development and disease
(Project Heads
Braun, Thomas
;
Yuan, Xuejun
;
Zhou, Ph.D., Yonggang
)
Pathways for BMP9/10 responsiveness in smooth muscle cells, critical for pulmonary hypertension and right heart failure
(Project Heads
Bellusci, Saverio
;
Braun, Thomas
)
Completed projects
Analyse der Entwicklung und Interaktion mesodermaler Gewebetypen von Vertebraten
(Project Head
Braun, Thomas
)
Characterization of Notch/RBP-J signaling in dependence of the cellular context during mesodermal differentiation
(Project Head
Just, Ursula
)
Die Rolle der Sir2alpha und Sir7 Gene in der Stressresistenz und Alterspräventation des Herzmuskels
(Project Head
Bober, Eva
)
Die Rolle der SIR2 Gene in der Herzalterung. Abhängigkeit vom oxidativen Stress
(Project Head
Bober, Eva
)
Kontrolle von Differenzierungs- und Regenerationsvorgängen im geschädigten und laternden Herzmuskel
(Project Head
Braun, Thomas
)
Molekulare Analyse der CMV-Genexpression zur Konstruktion von CMV-Vektoren
(Project Heads
Just, Ursula
;
Messerle, Martin
)
Molekulare Grundlagen der Innenohrentwicklung
(Project Head
Bober, Eva
)
Rolle von Phosphodiesterase-5 Inhibition in der Behandlung der chronisch thromboembolischen pulmonalen Hypertonie: Einfluss auf die pulmonale Hämodynamik und das rechtskardiale Remodeling
(Project Heads
Braun, Thomas
;
Ghofrani, Hossein Ardeschir
)
Untersuchung des regulatorischen Effektes von BMP-10 auf Proliferations- und Apoptosevorgänge im adulten und alternden Mausherzen
(Project Heads
Braun, Thomas
;
Neuhaus, Herbert
)
Zelluläre Antworten der Rechtsherzhypertrophie: Migration und Aktivierung kardiogener Zellen
(Project Head
Braun, Thomas
)
CRC/Transregios
Current projects
ncRNA control of multi-protein complex activity
(Project Heads
Braun, Thomas
;
Böttger, Thomas
)
Completed projects
Delineating the interplay of epigenetic modifiers and transcription factors in the control of muscle stem cell homeostasis and higher-order chromatin organization
(Project Heads
Braun, Thomas
;
Yuan, Xuejun
;
Zhou, Ph.D., Yonggang
)
Clinical Research Units
Completed projects
KFO 309: Virus-induced Lung Injury: Pathobiology and Novel Therapeutic Strategies
(Spokesperson
Seeger, Werner
)
Novel strategies for therapeutic programming and delivery of mesenchymal stem cells to improve outcome of influenza virus-induced lung injury
(Applicants
Braun, Thomas
;
Herold, Ph.D., Susanne Valerie
)
WBP Fellowship
Completed projects
Role of the SIRT7/NPM pathway in lung cancer progression
(Applicant
Ianni, Ph.D., Alessandro
)
International Research Training Groups
Completed projects
GRK 767: Transcriptional Control in Developmental Processes
(Spokesperson
Suske, Guntram
)
GRK 1062: Signalling Mechanisms in Lung Physiology and Disease (SMLPD)
(Spokesperson
Seeger, Werner
)
Research Training Groups
Current projects
GRK 2355: Regulatory networks in the mRNA life cycle: from coding to noncoding RNAs
(Spokesperson
Sträßer, Katja
)
Clusters of Excellence
Completed projects
EXC 147: Cardio-Pulmonary System
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
;
Zeiher, Andreas Michael
)
Clusters of Excellence (ExStra)
Current projects
EXC 2026: Cardio-Pulmonary Institute (CPI)
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
)
