Goethe-Universität Frankfurt am Main
Universitätsklinikum
Zentrum der Inneren Medizin
Medizinische Klinik 1
Address
Theodor-Stern-Kai 7
60596 Frankfurt am Main
Deutschland
GERiT
This institution in GERiT
60596 Frankfurt am Main
Projects
Research Grants
Current projects
Inflammation-driven Diseases Program (INDEEP): inflammatory response as driver for human diseases and target for therapy
(Applicant
Ullrich, Evelyn
)
The context-dependent role of IL-22 in chronic liver disease and acute-on-chronic liver failure
(Applicants
Schwarzkopf, Katharina Maria
;
Welsch, Christoph
)
Completed projects
Allosteric drugs targeting Aurora kinases for the treatment of cancer
(Applicant
Biondi, Ricardo M.
)
Development of allosteric inhibitors of AGC kinases and co-crystallography with the target kinases
(Applicants
Biondi, Ricardo M.
;
Engel, Matthias
)
Development of Analytical Tests for Detection of Pathogenicity and Identification of Molecular Defects in Unclear Genetic Variants of the DNA Mismatch Repair Gene MSH2 in Lynch Syndrome
(Applicant
Plotz, Guido
)
Hepatitis C virus related mechanisms for sensitivity to antiviral therapy
(Applicant
Sarrazin, Christoph M.
)
Modulation der experimentell-induzierten Colitis durch ein den IL-12-Rezeptor blockierendes IL-12p40 rekombinantes Protein
(Applicant
Zeuzem, Stefan
)
Molecular escape mechanisms due to patterns of resistance-associated amino acid variants in the hepatitis C virus NS3 protease
(Applicant
Welsch, Christoph
)
Molecular Mechanism of Regulation of the atypical Kinase C (PKC)
(Applicant
Biondi, Ricardo M.
)
Molecular Mechanism of Regulation of the Protein Kinase C-related Kinase 2 (PRK2)
(Applicant
Biondi, Ricardo M.
)
Molecular mechanisms of allosteric activation and inhibition by the PIF-pocket in AGC protein kinases
(Applicant
Biondi, Ricardo M.
)
Molecular mechanisms of cAMP-induced tyrosine phosphorylation of the receptors for EGF and NGF
(Applicant
Piiper, Albrecht
)
Regulation der Sekretion der Pankreasazinuszelle durch niedermolekulare GTP-bindende Rab3-Proteine
(Applicant
Zeuzem, Stefan
)
Role of microRNA-26b in the development of Hepatitis C Virus associated diffuse large B-cell lymphomas
(Applicant
Peveling-Oberhag, Jan
)
Role of the lipid environment in NS5A structural rearrangements and drug interactions in hepatitis C
(Applicant
Welsch, Christoph
)
Structural and Chemical-genetic approach to investigate the mechanisms underlying the protein kinases Pkh and Pkc1 (orthologues of PDK1 and PKC) in yeast.
(Applicant
Biondi, Ricardo M.
)
Untersuchung der Rolle von Tax1BP1 (Tax1-binding protein 1) bei der chronischen Entzündung, Karzinogenese und beim Proteinstoffwechsel
(Applicant
Waidmann, Oliver
)
Clinical Research Units
Completed projects
Bioinformatische und -statistische HCV-Sequenzanalyse
(Applicant
Welsch, Christoph
)
Charakterisierung des additiven antiviralen Effekts von Ribavirin
(Applicants
Hofmann, Wolf Peter
;
Mihm, Ulrike
)
HCV Sequenzanalysen und Therapieresistenzmechanismen
(Applicant
Sarrazin, Christoph M.
)
KFO 129: Mechanisms for Development of Resistance and Optimisation of Antiviral Strategies of Hepatitis C Virus Infection Comprising Integrative Biomathematical and Bioinformatical Models
(Spokesperson
Zeuzem, Stefan
)
Stochastische Modelle zur Hepatitis C Virus -und Quasispezieskinetik
(Applicant
Herrmann, Eva
)
Synthese und Wirkstoffdesign -Hemmung des CD81-vermittelten Hepatitis C-Virus Zelleintritts
(Applicant
Hartmann, Rolf
)
Zentralprojekt zur Koordinierung und wiss. Unterstützung der KFO 129
(Applicant
Zeuzem, Stefan
)
Research Fellowships
Completed projects
Entwicklung struktureller Deskriptoren zur NS3.4A Protease und Vorhersagen von STAT-C Resistenzen bei Peptidomimetika
(Applicant
Welsch, Christoph
)
WBP Fellowship
Current projects
Role of interferon signaling in hepatocyte senescence and metabolic changes in MASH and MASH-HCC
(Applicant
Alcober Boquet, Ph.D., Lucía
)
