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Goethe-Universität Frankfurt am Main
Universitätsklinikum
Institut für Biochemie I: Pathobiochemie

Address Theodor-Stern-Kai 7
60596 Frankfurt am Main
Deutschland

GERiT This institution in GERiT

60596 Frankfurt am Main

Projects

Research Grants
- Current projects
  - Characterisation of tumour heterogeneity in tissue slice cultures of head and neck tumours
    (Applicant Sönnichsen, Rasmus )
  - Impact of RNA-binding proteins and mRNA structures on alternative mechanisms of translational regulation in inflammation-associated tumorigenesis
    (Applicants Backofen, Rolf ; Schmid, Tobias )
- Completed projects
Research Units
- Completed projects
  - Einfluss bioaktiver Lipide aus apoptotischen Zellen auf den Makrophagenphänotyp
    (Applicant Brüne, Bernhard )
  - FOR 2438: Cell Plasticity in Colorectal Carcinogenesis
    (Spokesperson Greten, Florian R. )
  - S1P receptors shape immune cell plasticity in colorectal carcinoma
    (Applicants Brüne, Bernhard ; Weigert, Andreas )
  - Tumorigenic cytokine networks during colon carcinogenesis depend on sphingosine-1-phosphate receptor signalling
    (Applicants Brüne, Bernhard ; Weigert, Andreas )
Priority Programmes
- Current projects
  - Macrophages in sensing and executing ferroptosis
    (Applicants Brüne, Bernhard ; Fuhrmann, Dominik )
Collaborative Research Centres
- Current projects
  - Autophagy mechanisms in intercellular sensing of tissue homeostasis by the immune system
    (Project Heads Herhaus, Lina ; Weigert, Andreas )
  - Inhibition of ether-phosphatidylserine synthesis and signaling for tumor therapy
    (Project Head Weigert, Andreas )
  - Regulation and function of 15-lipoxygenase-2
    (Project Head Brüne, Bernhard )
  - Regulation of lipid metabolism by ER-mitochondrial contact sites in macrophages
    (Project Head Namgaladze, Dmitry )
- Completed projects
  - Administration
    (Project Heads Brandes, Ralf P. ; Brüne, Bernhard )
  - Consequences of chronic hypoxia and HIF-1/HIF-2 in regulating function and plastic-ity of macrophages and tumor cells
    (Project Head Brüne, Bernhard )
  - Regulation und funktion des Proteasoms und der PPAR-Y-Expression bei der NO-vermittelten Apoptose und dem Schutz von Makrophagen
    (Project Heads Brüne, Bernhard ; von Knethen, Andreas )
  - SFB 815: Redox-Regulation: Generating Systems and Functional Consequences
    (Spokesperson Brüne, Bernhard )
  - Tubuloepitheliale und mesangiale Zellschädigung und Protektion durch Redoxsignale
    (Project Head Brüne, Bernhard )
Clinical Research Units
- Completed projects
  - Bedeutung von oxidativem Streß für die Endothelfunktionsstörung bei Patienten mit arterieller Hypertonie
    (Applicant John, Stefan )
Research Training Groups
- Current projects
  - GRK 2336: Resolution of inflammation – Mediators, signaling and therapeutic options
    (Spokesperson Brüne, Bernhard )
- Completed projects
  - GRK 1172: Research, Development and Safety of Biologicals
    (Spokesperson Pfeilschifter, Josef M. )
International Research Training Groups
- Completed projects
  - GRK 757: Roles of Eicosanoids in Biology and Medicine
    (Spokesperson Steinhilber, Dieter )

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