Universitätsklinikum Heidelberg
Medizinische Klinik, Innere Medizin IV
Klinik für Gastroenterologie, Infektionskrankheiten und Vergiftungen
Address
Im Neuenheimer Feld 410
69120 Heidelberg
Deutschland
GERiT
This institution in GERiT
69120 Heidelberg
Projects
Research Grants
Current projects
Characterization of the gut mucosa transcriptome in extraintestinal cancer and ICI-responders & Development of a gut mucosa-based biomarker score to predict response to gut microbiome-based interventions
(Applicants
Rauber, Conrad
;
Roberti, Ph.D., Maria Paula
)
Infiltrative monocytes modulated by adenosine deaminase 2 promote tissue inflammation and fibrosis in Crohn's disease
(Applicant
Tiwari-Heckler, Shilpa
)
Completed projects
Alterations of the expression pattern in bile-duct epithelia and the bile-proteome in primary sclerosing cholangitis: Identification of disease-associated proteins by a proteomic approach
(Applicants
Gotthardt, Daniel
;
Rupp, Christian
)
Characterization and targeting of cathepsin B and L activity in tumor-associated macrophages during pancreatic cancer development and progression.
(Applicant
Michl, Patrick
)
Charakterisierung der zellulären und humoralen Immunantwort nach DNA-Immunisierung gegen verschiedene Genotypen und Subtypen des Hepatitis C Virus - Entwicklung einer Multi-Genotyp-Vakzine gegen Hepatitis C Virus
(Applicant
Encke, Jens
)
Development of targeted retroviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins
(Applicant
Springfeld, Christoph
)
Die Modulation der p53- und c-myc-Promotoraktivität durch das Hepatitis C Virus Core-Protein
(Applicant
Stremmel, Wolfgang
)
Elucidating the mechanism of transendothelial fatty acid transport
(Applicant
Füllekrug, Joachim
)
Entwicklung und Charakterisierung einer Tetrazyklin-regulierbaren Hepatitis C Virus transgenen Maus als Hepatitis C Tiermodell
(Applicant
Encke, Jens
)
Funktionelle Untersuchungen zur Pathophysiologie der bei Morbus Wilson beobachteten hepatischen Eisenüberladung
(Applicant
Merle, Uta
)
Identifizierung neuer Effektoren des Transkriptionsfaktors CUTL1 beim Pankreaskarzinom mit Hilfe der RNA Interference-Library-Technologie
(Applicant
Michl, Patrick
)
Intracellular channeling of fatty acids by acyl-CoA synthetases
(Applicant
Füllekrug, Joachim
)
Intrazelluläre Lokalisation, physiologische Funktion und Regulation von FATP4, einem putativen Schlüsselprotein für die zelluläre Aufnahme langkettiger Fettsäuren
(Applicant
Stremmel, Wolfgang
)
In vivo characterization of CUX1 in tumorigenesis and tumor progression in pancreatic cancer
(Applicant
Michl, Patrick
)
Mechanismen der Apoptoseregulation durch TRAIL-Rezeptor 4 in primären humanen Hepatozyten und hepatozellulären Karzinomen
(Applicant
Ganten, Tom
)
Mode of action of the bile-acid phospholipid conjugate ursodeoxycholyl-lysophosphatidylethanolamide (UDCA-LPE) on fatty acid uptake in hepatocytes: implication for its therapeutic use in non-alcoholic steatohepatitis (NASH).
(Applicant
Stremmel, Wolfgang
)
Modulation of Membrane Phospholipids by Hepatic Deficiency of iPLA2beta Renders Hepatitis Susceptibility in Non-obese but Protects against Steatosis in Obese Mice
(Applicant
Chamulitrat, Ph.D., Walee
)
Molekularer Mechanismus der Eisenüberladung bei Hämochromatose am Modell einer Cys282Tyr-HFE exprimierenden Zelllinie sowie einer generierten HFE-Knockoutmaus
(Applicant
Stremmel, Wolfgang
)
Pathomechanismus der Fettstoffwechselstörung der Caveoloin-1 Knock-out-Maus
(Applicant
Pohl, Jürgen
)
Protective functions of the bile acid phospholipid conjugate Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) during hepatofibrogenesis
(Applicant
Pathil-Warth, Anita
)
Role of gp91phox homolog Nox1 in Cell Transformation of Human Keratinocytes
(Applicant
Chamulitrat, Ph.D., Walee
)
The function of the fatty acyl-CoA synthetase ACSL3 in the dynamic metabolism of lipid droplets
(Applicant
Füllekrug, Joachim
)
Research Fellowships
Completed projects
Einfluß der Proteinkinase Akt/PKB und deren downstream target YAP auf die p53-vermittelte Apoptose bei soliden Tumoren
(Applicant
Michl, Patrick
)
Evaluation of Intrahepatic Immune and Virological Mechanisms of Immunopathology in Chronic Hepatitis B Patients using Fine Needle Aspiration Biopsy
(Applicant
Nkongolo, Shirin
)
Natural killer T (NKT)-cell mediated tissue injury is modulated by CD39 in models of nonalcoholic fatty liver disease.
(Applicant
Tiwari-Heckler, Shilpa
)
Recombinant measles viruses with enhanced cytotoxicity for the therapy of malignant diseases
(Applicant
Springfeld, Christoph
)
Regulation der Sensitivität von Tumorzellen durch Chemotherapeutika auf TRAIL-induzierte Apoptose am Beispiel des Hepatozellulären Karzinom
(Applicant
Ganten, Tom
)
Clinical Research Units
Completed projects
Genome-wide analysis of the CUX1 transcriptional network mediating resistance to apoptosis in pancreatic cancer
(Applicant
Michl, Patrick
)
Research Units
Current projects
FOR 5815: Structural and functional lipid droplet heterogeneity
(Spokesperson
Herker, Eva
)
Function of perilipin 3 in lipid droplet heterogeneity and metabolism
(Applicant
Füllekrug, Joachim
)
Collaborative Research Centres
Completed projects
SFB 601: Molekulare Pathogenese hepato-gastroenterologischer Erkrankungen
(Spokesperson
Stremmel, Wolfgang
)
Untersuchungen zur Funktion des Hämochromatosegens HLA-H bei der Regulation der intestinalen Eisenaufnahme
(Project Heads
Riedel, Hans-Dieter
;
Stewart, Adrian Francis
;
Stremmel, Wolfgang
)
Zelluläre Aufnahme langkettiger Fettsäuren: eine konzentrierte Aktion gesteuert von Angebot und Nachfrage
(Project Head
Stremmel, Wolfgang
)
Zentrale Verwaltungsaufgaben für den SFB
(Project Head
Stremmel, Wolfgang
)
CRC/Transregios
Current projects
Characterization of hepatitis D virus cell division-mediated spread and interference through innate and adaptive immune responses
(Project Heads
Nkongolo, Shirin
;
Urban, Stephan
)
Effects of constitutive cytokine signalling on tissue homeostasis and liver cell-intrinsic responsiveness to hepatitis virus infection
(Project Heads
Beisel, Claudia
;
Binder, Marco
;
Pichlmair, Andreas
)
Clinical Trials
Completed projects
Covered transjugular intrahepatic portosystemic stent shunt versus optimezed medical treatment for the secondary prevention of variceal bleeding in cirrhosis
(Applicant
Sauerbruch, Tilman
)
Research Training Groups
Current projects
GRK 2751: Inflammatory cues as modulators of early pancreatic carcinogenesis (InCuPanC)
(Spokesperson
Rosendahl, Jonas
)
