Universität Leipzig
Institut für Organische Chemie
Address
Johannisallee 29
04103 Leipzig
Deutschland
GERiT
This institution in GERiT
04103 Leipzig
Projects
Research Grants
Current projects
Catalytic, enantioselective alkylation of 1-azaallyl cations with silylketene acetals
(Applicant
Schneider, Christoph
)
Catalytic, Enantioselective Piancatelli Rearrangement
(Applicant
Schneider, Christoph
)
Catalytic Indole Synthesis through Aza-Nazarov Rearrangement of a-Hydroxy Oxime Ethers. Atropselective Synthesis of Axially Chiral 3-Arylindoles
(Applicant
Schneider, Christoph
)
Design of flavoproteins for spin-hyperpolarization in NMR
(Applicants
Matysik, Jörg
;
Zeitler, Kirsten
)
Development of symmetrical cyclononynes for intracellular generation of protein-protein interaction inhibitors by isomer-free, strain-promoted cycloadditions
(Applicant
Berg, Thorsten
)
Selective targeting of the highly homologous transcription factors STAT5a and STAT5b by small-molecule inhibitors of protein-protein interactions
(Applicant
Berg, Thorsten
)
Understanding and Controlling Reactions in Charge-imbalanced Layers of Soft-landed Ions by Precise Tuning of Surface Properties
(Applicants
Anders, André
;
Warneke, Jonas
;
Zeitler, Kirsten
)
Completed projects
A Convergent, Flexible, and Stereoselective Total Synthesis of the Dimeric Nuphar Alkaloids 6-Hydroxy-Thionuphlutine and 6-Hydroxy-Thiobinupharidine
(Applicant
Schneider, Christoph
)
Aldol-Tishchenko-Reaktionen mit Ketonaldoladdukten als Enoläquivalenten zur direkten, katalytischen und enantioselektiven Synthese polyhydroxylierter Verbindungen
(Applicant
Schneider, Christoph
)
A new principle for the functional inhibition of protein-protein interactions
(Applicant
Berg, Thorsten
)
Bioorthogonal generation of high-affinity inhibitors of protein-protein interactions
(Applicant
Berg, Thorsten
)
Catalytic, Asymmetric Halogenations mediated by hypervalent Iodanes
(Applicant
Gulder, Tanja
)
Development of inhibitors of the protein-protein interaction domain of the transcription factor STAT4
(Applicant
Berg, Thorsten
)
Efficient, catalytic, asymmetric crossed acyloin condensations
(Applicant
Zeitler, Kirsten
)
Eine effiziente Strategie zur regioselektiven Funktionalisierung von mehrfunktionellen alpha-Amino-, alpha-Hydroxy- und alpha-Mercaptosäuren
(Applicant
Burger, Klaus
)
Eine konvergente und einheitliche Strategie zum Aufbau höherer Polydeoxypropionat-Naturstoffe - stereoselektive Synthesen der Membranlipidkomponenten Mycoceran- , Phthioceran- und Hydroxyphthioceransäure aus M. tuberculosis
(Applicant
Schneider, Christoph
)
Enantioselective, Brønsted acid-catalyzed cycloadditions of alkylidene-2H- and alkylidene-3H-pyrroles towards the rapid and stereoselective assembly of bicyclic nitrogen heterocycles
(Applicant
Schneider, Christoph
)
Enantioselektive, Metall-katalysierte Ringöffnung von meso-Aziridinen - ein einfacher und direkter Zugang zu hochenantiomerangereicherten, ß-funktionalisierten Aminen
(Applicant
Schneider, Christoph
)
Enantio- und diastereoselektive, katalytische, vinyloge Mukaiyama-Mannich- und Mukaiyama-Michael-Reaktionen acyclischer Silyldienolate
(Applicant
Schneider, Christoph
)
Erste Totalsynthese des Polyen-Makrolid-Antibiotikums RK-397 durch eine neuartige Polyolsynthese-Strategie und Aufklärung seiner relativen und absoluten Konfiguration
(Applicant
Schneider, Christoph
)
Fluoreszenzspektroskopische Untersuchungen von Wechselwirkungsphänomenen am GM2-Aktivatorprotein, dem "penicillin binding protein 1b" und der Ribonuclease T1
(Applicant
Blume, Alfred
)
Inter- und intramolecular, phosphoric acid-catalyzed reactions of in situ-generated ortho-quinone methides and ortho-quinone methide imines towards the enantioselective synthesis of benzoannulated oxygen and nitrogen heterocycles
(Applicant
Schneider, Christoph
)
Katalytische, enantioselektive Addition von Alkoholen, Aminen, Thiolen und C-Nucleophilen an meso-Epoxide mit Hilfe eines universellen chiralen Scandium-Bipyridin-Komplexes
(Applicant
Schneider, Christoph
)
Moenomycin A als Werkzeug zur Aufklärung von Struktur und Wirkungsweise des Transglycosylierungsenzyms bei der Peptidoglycanbiosynthese und als Leitstruktur für neuartige Antibiotika
(Applicant
Welzel, Peter
)
Molekulare Erkennung der Adenylylcyclase durch Forskolin Synthetische, strukturelle und funktionelle Aspekte, Anwendungsperspektiven
(Applicant
Welzel, Peter
)
Molekulare Erkennung von chemotaktischen Peptiden und Chemokinen
(Applicant
Burger, Klaus
)
Neue, potentiell photochrome Spiroverbindungen via Ringtransformation von Heterocyclen
(Applicant
Zimmermann, Thomas
)
Simultane Inhibition von katalytischen Domänen und Protein-Protein-Wechselwirkungsdomänen als Ansatz zur Generierung monospezifischer Kinaseinhibitoren am Beispiel von Plk1
(Applicant
Berg, Thorsten
)
Synthese und biologische Evaluierung von Cyclopamin und seiner Analoga als Inhibitoren des Hedgehog-Signaltranduktionsweges
(Applicant
Giannis, Athanassios
)
Synthese und biologische Evaluierung von Inhibitoren der Acyl-Protein Thioesterase 1 (APT1) zur Untersuchung der biologischen Bedeutung der reversiblen Protein-Palmitoylierung
(Applicant
Giannis, Athanassios
)
Synthese und biologische Testung von Inhibitoren der Acyl-Protein Thioesterase APT1 zur Untersuchung der biologischen Bedeutung der reversiblen Protein-Palmitoylierung
(Applicant
Waldmann, Herbert
)
Totalsynthese des Mikrotubuli-stabilisierenden marinen Naturstoffs (+)-Pelorusid A und Untersuchung von Struktur-Aktivitätsbeziehungen an analogen Verbindungen
(Applicant
Schneider, Christoph
)
Total synthesis and biological evaluation of C-nor-D-homo Steroids
(Applicant
Giannis, Athanassios
)
Priority Programmes
Completed projects
Enantioselektive, Bronsted-Säure-kalalysierte, vinyloge Mannich- und Michael-Reaktionen
(Applicant
Schneider, Christoph
)
Integration carbenkatalytisch generierter Intermediate in organokatalytische Domino- und Kaskadenreaktionen
(Applicant
Zeitler, Kirsten
)
Research Units
Completed projects
Continuous flow synthesis of sulfur heterocycles via cycloaddition reactions of photochemically generated transient thioaldehydes
(Applicant
Schneider, Christoph
)
FOR 2177: Integrated Chemical Micro Laboratories
(Spokesperson
Belder, Detlev
)
Impedimetric monitoring in microfluidic reaction systems for small molecule detection in flow
(Applicant
Robitzki, Andrea A.
)
Multicatalytic synthesis with 1,3-dipoles in microfluidic systems
(Applicant
Zeitler, Kirsten
)
Multistep chip reactors with an integrated continuous separation
(Applicant
Belder, Detlev
)
Synergistic Photocatalysis with short-lived intermediates in microfluidic systems
(Applicant
Zeitler, Kirsten
)
Thiamine-inspired novel organocatalytic reactions with heterazolium precatalysts
(Applicant
Zeitler, Kirsten
)
Emmy Noether Independent Junior Research Groups
Completed projects
Learning from natures's lessons: development of bioinspired catalysts for selective oxidative halogenations and their application for the creation of potent biomedical agents
(Applicant
Gulder, Tanja
)
Heisenberg Professorships
Completed projects
Biomimetic Catalysis
(Applicant
Gulder, Tanja
)
WBP Position
Current projects
Fluorinations and Pentafluorosulfanylations via Upcycling of the Greenhouse Gas Sulfurhexafluoride: CatalyticFix-SF6
(Applicant
Biswas, Ph.D., Aniruddha
)
Research Fellowships
Completed projects
Asymmetric synthesis of substituted tetrahydro-gamma- carbolines and pyrrolo-[4,3,2 de]isochinolines by "Iso" Pictet-Spengler reactions with ciral silans as Lewis acids and biological testing of the novel N-heterocycles
(Applicant
Schönherr, Heike
)
Total Synthesis of the Terpenoid Phthalazinone Azamerone
(Applicant
Gulder, Tanja
)
Major Research Instrumentation
Completed projects
400 MHz FT-NMR-Spektrometer
400 MHz NMR console with probe and autosampler
600 MHz-spectrometer with probes and autosampler
Screening-Roboter
CRC/Transregios
Current projects
Base-Promoted Oxidative PCET Remote Functionalization
(Project Head
Zeitler, Kirsten
)
Design and application of novel TADF compounds for triplet–triplet upconverting photocatalysis
(Project Heads
Deibel, Carsten
;
Zeitler, Kirsten
)
Molecular thermally activated delayed fluorescence emitters and their spin-dynamics
(Project Heads
Deibel, Carsten
;
Wiebeler, Christian
;
Zeitler, Kirsten
)
Photochemical Polyene Cyclizations in Microheterogenous, Fluorinated Environments
(Project Head
Gulder, Tanja
)
Solid-state photo-CIDNP NMR applying flavin systems
(Project Heads
Gulder, Tanja
;
Matysik, Jörg
;
Solovyov, Ph.D., Ilia
)
Completed projects
Synthesis and allocation of oligomeric and polymeric glycosaminoglycans and artificial extracellular matrices
(Project Heads
Giannis, Athanassios
;
Scharnweber, Dieter
;
Schiller, Jürgen
;
Schnabelrauch, Matthias
)
Research Training Groups
Current projects
GRK 2721: Hydrogen Isotopes 1,2,3H
(Spokesperson
Asmis, Knut R.
)
GRK 3082: Engineering covalent bonds in molecules and materials
(Spokesperson
Scheschkewitz, David
)
Completed projects
GRK 378: Mechanisms and Applications of Non-Conventional Oxidation Reactions
(Spokesperson
Hey-Hawkins, Evamarie
)
