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Universitätsklinikum Würzburg
Zentrum Innere Medizin
Medizinische Klinik und Poliklinik II

Address Oberdürrbacher Straße 6
97080 Würzburg
Deutschland

GERiT This institution in GERiT

97080 Würzburg

Projects

Research Fellowships
- Current projects
  - CRISPR-based functional genomics to dissect the regulation of multiple myeloma cell responses to perturbations of mutant RAS function: biological and therapeutic implications.
    (Applicant Steinbrunn, Torsten )
- Completed projects
Research Grants
- Current projects
  - Identification of the early footprint of myeloma bone disease: spatio-temporal mapping and quantifying of extracellular matrix biomarkers in murine model and human bone biopsies
    (Applicants Jundt, Franziska ; Zaslansky, Paul )
  - Impact of obesity and hyper/hypo-mechanical loading on myeloma bone disease
    (Applicants Ebert, Regina ; Jundt, Franziska )
- Completed projects
Clinical Research Units
- Current projects
  - Bortezomib-induced painful neuropathy: risk factors, resilience and resolution
    (Applicants Einsele, Hermann ; Kortüm, Martin ; Sommer, Claudia )
  - KFO 5001: Peripheral mechanisms of pain and their resolution
    (Spokesperson Sommer, Claudia )
- Completed projects
Research Units
- Current projects
  - FOR 2830: Advanced Concepts in Cellular Immune Control of Cytomegalovirus
    (Spokesperson Dölken, Lars )
  - Personalized medicine - Risk stratification and prevention of HCMV-related disease in transplant patients based on MHC-I-ligandomes
    (Applicants Einsele, Hermann ; Kraus, Sabrina )
- Completed projects
Independent Junior Research Groups
- Current projects
  - Prime-CAR Inspection: Enhancing Cancer-Directed CAR-T Cells with Safety-Validated CRISPR Prime Editors
    (Applicant Petri, Karl )
Collaborative Research Centres
- Completed projects
Priority Programmes
- Current projects
  - Molecular dissection of signaling pathways exerting bone anabolic and anti-tumor effects of physical stimuli in myeloma bone disease
    (Applicants Ebert, Regina ; Jundt, Franziska )
- Completed projects
  - Analysis of the interaction between Aspergillus fumigatus and human dendritic cells and the induction of innate and adaptive immune responses to the pathogen
    (Applicant Einsele, Hermann )
  - Analysis of the interaction between Aspergillus fumigatus and human immune effector cells and the induction of innate and adaptive immune responses to the pathogen
    (Applicant Einsele, Hermann )
CRC/Transregios
- Current projects
  - Advanced CAR T cell engineering to augment the graft-versus-leukemia effect of allogeneic HSCT
    (Project Heads Einsele, Hermann ; Hudecek, Michael )
  - Bench-to-Bedside Advanced Therapy Medicinal Product (ATMP) Development Platform
    (Project Heads Einsele, Hermann ; Hildebrandt, Martin ; Marckmann, Georg ; Priesner, Christoph )
  - Engineering of CAR-T cells that overcome MYC-dependent immunosuppression in a genetically engineered mouse model of pancreatic cancer
    (Project Heads Danhof, Sophia ; Eilers, Martin )
  - Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection
    (Project Heads Einsele, Hermann ; Hudecek, Michael )
  - Interaction of Aspergillus fumigatus with human natural killer cells
    (Project Heads Einsele, Hermann ; Löffler, Jürgen ; Terpitz, Ulrich )
  - Novel tri-specific T-cell activating antibodies for personalized graft-versus-leukemia therapy
    (Project Heads Bargou, Ralf C. ; Bumm, Thomas ; Mokhtari, Ph.D., Zeinab ; Stuhler, Gernot )
  - One CAR – multiple antigens: Universal CAR-T cells that are chemically programmed to recognize tumors
    (Project Head Hudecek, Michael )
- Completed projects
Major Research Instrumentation
- Completed projects
  - High throughput cell separation device
  - Optofluidic single-cell analysis platform
DFG Research Centres
- Completed projects
  - Junior Research Groups
    (Project Head Hermanns, Heike M. )
Research Training Groups
- Completed projects
  - GRK 520: Immunomodulation
    (Spokesperson Hünig, Thomas )
Graduate Schools
- Completed projects
  - GSC 106: Graduate School for Life Sciences (GSLS)
    (Spokesperson Kisker, Caroline )

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