Universitätsklinikum Würzburg
Zentrum Innere Medizin
Medizinische Klinik und Poliklinik II
Address
Oberdürrbacher Straße 6
97080 Würzburg
Deutschland
GERiT
This institution in GERiT
97080 Würzburg
Projects
Research Fellowships
Completed projects
CRISPR-based functional genomics to dissect the regulation of multiple myeloma cell responses to perturbations of mutant RAS function: biological and therapeutic implications.
(Applicant
Steinbrunn, Torsten
)
Die Analyse von Dlx-genabhängigen Zellmigrationen im Vorderhirn der Maus
(Applicant
Stühmer, Thorsten
)
Engineering von ROR1-spezifischen CD8+ T-Zellen zur adoptiven Immuntherapie bei chronischer lymphatischer Leukämie
(Applicant
Hudecek, Michael
)
Maximizing CRISPR-Cas off-target detection sensitivity using high-density DNA chip synthesis.
(Applicant
Petri, Karl
)
Research Grants
Current projects
Identification of the early footprint of myeloma bone disease: spatio-temporal mapping and quantifying of extracellular matrix biomarkers in murine model and human bone biopsies
(Applicants
Jundt, Franziska
;
Zaslansky, Paul
)
Impact of obesity and hyper/hypo-mechanical loading on myeloma bone disease
(Applicants
Ebert, Regina
;
Jundt, Franziska
)
Completed projects
Adaptive response of bone to mechanical strain in a mouse model of myeloma bone disease
(Applicant
Jundt, Franziska
)
Charakterisierung der Expressions- und Aktivitätsveränderungen von Karzinogen-Transportern in entzündlich oder neoplastisch verändertem Darmepithel
(Applicant
Geier, Andreas
)
Charakterisierung der immunologischen und pathobiologischen Funktionen einer permanenten NF-kB Aktivität für die Entstehung von Hodgkin-Lymphomen
(Applicant
Jundt, Franziska
)
Effects of SRC kinase inhibitors on antigen specific T-cell-activation and proliferation
(Applicant
Seggewiss-Bernhardt, Ruth
)
Functional validation of novel drug targets in multiple myeloma by use of a targeted shRNA library
(Applicant
Jundt, Franziska
)
Involvement of the intracranial vessels in systemic diagnostic investigation of vasulitis using MRI
(Applicants
Bley, Thorsten
;
Hennig, Jürgen
)
Signal transduction in CLL B-cells: identification of CD23 interaction partners
(Applicant
Goller, Martin Ernst
)
Signaltransduktion der IL-6-Typ Zytokine in Keratinozyten und deren Konsequenz für die Expression der polyspezifischen membranständigen Transportproteine und Cytochrom P450-Enyzme
(Applicant
Baron, Jens Malte
)
Clinical Research Units
Current projects
KFO 5001: Peripheral mechanisms of pain and their resolution
(Spokesperson
Sommer, Claudia
)
Resolution of neuropathies caused by bortezomib and its successor drugs
(Applicants
Einsele, Hermann
;
Kortüm, Martin
;
Sommer, Claudia
)
Completed projects
Centralized sample preparation, pathology and preclinical in vivo models
(Applicants
Beilhack, Andreas
;
Einsele, Hermann
;
Rosenwald, Andreas
)
Characterization of RAS-dependent effector signaling pathways in multiple myeloma
(Applicants
Bargou, Ralf C.
;
Chatterjee, Manik
;
Steinbrunn, Torsten
)
gamma delta T-Zellen im Tumormikromilieu - Modulation der Tumorantigenspezifischen alpha beta T-Zell Immunantwort durch gamma delta T-Zellen
(Applicant
Kunzmann, Volker
)
KFO 216: Characterisation of the Oncogenic Signalling Network in Multiple Myeloma: Development of Targeted Therapies
(Spokesperson
Einsele, Hermann
)
Regulation, integration and impact of NFkB-signaling within the oncogenic signaling network in multiple myeloma
(Applicants
Siegmund, Daniela
;
Stühmer, Thorsten
;
Wajant, Harald Günther
)
The heat shock protein/signaling interface as a therapeutic target in multiple myeloma and in Graft-versus-Host-Disease
(Applicants
Chatterjee, Manik
;
Einsele, Hermann
)
Ursachen und Wirkungen von Transkriptionsfaktordefekten beim Morbus Hodgkin
(Applicant
Jundt, Franziska
)
Research Units
Current projects
FOR 2830: Advanced Concepts in Cellular Immune Control of Cytomegalovirus
(Spokesperson
Dölken, Lars
)
Personalized medicine - Risk stratification and prevention of HCMV-related disease in transplant patients based on MHC-I-ligandomes
(Applicants
Einsele, Hermann
;
Kraus, Sabrina
)
Completed projects
Automated design of a scalable, additively manufactured robot system for microinvasive interventions in visceral medicine
(Applicants
Lüth, Tim C.
;
Meining, Alexander
)
Defekte transkriptionelle Aktivierung in Tumoren lymphatischer Gewebe
(Applicant
Serfling, Edgar
)
Evaluierung eines neuen mechatronischen Single-Port-Systems für endoluminale-endoskopische und NOTES-gesteuerte Interventionen
(Applicant
Feussner, Ph.D., Hubertus
)
FOR 1321: Single-Port Technology for Gastroenterological and Surgical Endoscopic Interventions
(Spokesperson
Feussner, Ph.D., Hubertus
)
Koordinatorenfond: Single-Port-Technologie für gastroenterologische und viszeralchirurgische endoskopische Interventionen
(Applicant
Feussner, Ph.D., Hubertus
)
Emmy Noether Independent Junior Research Groups
Current projects
Prime-CAR Inspection: Enhancing Cancer-Directed CAR-T Cells with Safety-Validated CRISPR Prime Editors
(Applicant
Petri, Karl
)
Collaborative Research Centres
Completed projects
Induktion und Manipulation HCMV-spezifischer T-Zellantworten
(Project Heads
Einsele, Hermann
;
Jahn, Gerhard J.
)
Molekulare Mechanismen der Oncostatin M-vermittelten Signaltransduktion und deren Bedeutung in der Entzündung
(Project Head
Hermanns, Heike M.
)
Multimodal Imaging of Vascularization and Angiogenesis for Monitoring and Selection of Treatment of Colorectal Neoplasia
(Project Head
Meining, Alexander
)
Regulation der Herpesvirus-spezifischen T-Zellen Immunität
(Project Heads
Einsele, Hermann
;
Topp, Max-Stanley
)
Relevance of IL-6 receptor gp130 endocytosis to control inflammatory processes in the cardiovascular system
(Project Heads
Ertl, Georg
;
Frantz, Stefan
;
Hermanns, Heike M.
)
Strukturelle Grundlagen der Zytokinrezeptor-vermittelten Aktivierung des JAK/STAT- und MAPK-Signalwegs
(Project Head
Hermanns, Heike M.
)
Transkriptionelle Regulation hepatobiliärer organischer Anionentransporter durch proinflammatorische Zytokine
(Project Head
Geier, Andreas
)
Priority Programmes
Current projects
Molecular dissection of signaling pathways exerting bone anabolic and anti-tumor effects of physical stimuli in myeloma bone disease
(Applicants
Ebert, Regina
;
Jundt, Franziska
)
Completed projects
Analysis of the interaction between Aspergillus fumigatus and human dendritic cells and the induction of innate and adaptive immune responses to the pathogen
(Applicant
Einsele, Hermann
)
Analysis of the interaction between Aspergillus fumigatus and human immune effector cells and the induction of innate and adaptive immune responses to the pathogen
(Applicant
Einsele, Hermann
)
CRC/Transregios
Current projects
Advanced CAR T cell engineering to augment the graft-versus-leukemia effect of allogeneic HSCT
(Project Heads
Einsele, Hermann
;
Hudecek, Michael
)
Bench-to-Bedside Advanced Therapy Medicinal Product (ATMP) Development Platform
(Project Heads
Einsele, Hermann
;
Hildebrandt, Martin
;
Marckmann, Georg
;
Priesner, Christoph
)
Engineering of CAR-T cells that overcome MYC-dependent immunosuppression in a genetically engineered mouse model of pancreatic cancer
(Project Heads
Danhof, Sophia
;
Eilers, Martin
)
Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection
(Project Heads
Einsele, Hermann
;
Hudecek, Michael
)
Interaction of Aspergillus fumigatus with human natural killer cells
(Project Heads
Einsele, Hermann
;
Löffler, Jürgen
;
Terpitz, Ulrich
)
Novel tri-specific T-cell activating antibodies for personalized graft-versus-leukemia therapy
(Project Heads
Bargou, Ralf C.
;
Bumm, Thomas
;
Mokhtari, Ph.D., Zeinab
;
Stuhler, Gernot
)
One CAR – multiple antigens: Universal CAR-T cells that are chemically programmed to recognize tumors
(Project Head
Hudecek, Michael
)
Completed projects
Functional Dissection and Targeting of aberrant Differentiation through deregulated Notch Signaling in Hodgkin Lymphoma and multiple Myeloma
(Project Heads
Dörken, Bernd
;
Jundt, Franziska
)
Impact of regulatory T cells on human infections caused by Aspergillus fumigatus
(Project Head
Topp, Max-Stanley
)
Relevance and molecular mechanisms of zinc homeostasis in megakaryo-poiesis and platelet function
(Project Heads
Braun, Ph.D., Attila Laszlo
;
Hermanns, Heike M.
)
Role of platelet-mediated resolution-regeneration programmes of bacterial-induced sepsis
(Project Heads
Hermanns, Heike M.
;
Mirakaj, Valbona
;
Stegner, David
)
Major Research Instrumentation
Completed projects
High throughput cell separation device
Optofluidic single-cell analysis platform
DFG Research Centres
Completed projects
Junior Research Groups
(Project Head
Hermanns, Heike M.
)
Research Training Groups
Completed projects
GRK 520: Immunomodulation
(Spokesperson
Hünig, Thomas
)
Graduate Schools
Completed projects
GSC 106: Graduate School for Life Sciences (GSLS)
(Spokesperson
Kisker, Caroline
)
